The first Co-design Lab that took place in September-October 2021 addressed the Gender STI objectives to integrate the gender perspective in bilateral and multilateral agreements between the EU Member States (MS), Associated Countries (AC) and third countries through design thinking methods and participatory techniques. The document describes the methods, participatory steps and tools that have been applied in the first LAB to co-design shared solutions and prototypes for common challenges regarding gender inequalities in STI and to support the emergence of an international community of practitioners with similar challenging objectives.