This report targets policymakers, stressing the necessity of policy coherence, evidence-based approaches, and gender-disaggregated monitoring in science, technology, and innovation (STI) policies. It advocates for gender assessments in all STI policies, emphasizing concrete actions like gender-responsive budgeting. Through a range of global case studies, the report showcases best practices for integrating a gender lens into STI policy analysis, design, and implementation. Its goal is to enhance the effectiveness of STI policies by acknowledging women's contributions and unique needs, thereby promoting social equity and economic development.