This framework developed by the European Commission provides guidance for integrating and evaluating inclusive gender analysis in research and innovation (R&I) content across the European Research Area. Developed under ERA Action 5, it promotes a systemic, intersectional approach that considers sex, gender, and other inequality factors in R&I. The document outlines policy developments, progress, key challenges, and principles to support national authorities and research funding organisations. It emphasizes inclusive terminology, consistent indicators, comprehensive monitoring, and engagement of all R&I actors, including the business sector. The framework aims to enhance research quality, societal relevance, and support for the digital and green transitions.